MXene-Based Aptasensor: Characterization and High-Performance Voltammetry Detection of Deoxynivalenol

Sangu, S.S. and Illias, N.M. and Ong, C.C. and Gopinath, S.C.B. and Saheed, M.S.M. (2021) MXene-Based Aptasensor: Characterization and High-Performance Voltammetry Detection of Deoxynivalenol. BioNanoScience, 11 (2). pp. 314-323.

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Deoxynivalenol (DON) is a mycotoxin secreted by Fusarium species members, and the consumption of which causes a serious health issue. In this work, MXene is used to generate a highly sensitive and selective biosensing system for DON. MXene is prepared by the selective etching of aluminum from titanium aluminum carbide (Ti3AlC2-MAX) powder using hydrochloric acid-lithium fluoride (HCl-LiF). The prepared MXene surface is immobilized with a tailor-made DON aptamer, and its affinity towards DON is measured using a sweep voltammetry. Field emission scanning electron microscopy (FESEM) displays the intercalation between MXene layers indicating the successful etching of aluminum. Energy-dispersive X-ray spectroscopy study confirms the incident elemental compositions, whereas X-ray photoelectron spectroscopy analysis shows a high composition of Ti-Fx and TiO2, due to the replacement of the aluminum layers with oxygen and fluorine terminations. The presence of oxygen is beneficial for surface modification and biomolecular immobilization as attested by the Fourier-transform infrared spectroscopy peak profile. The aptasensor shown here has a high sensitivity with a limit of detection at 1 fg mL�1 and demonstrates a remarkable selectivity towards DON by discriminating the binding of similar mycotoxins, zearalenone, and ochratoxin A and with DON-spiked paddy extract. This simple yet cost-effective high-performance detection of DON can be an alternative strategy for screening food and feed samples. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Item Type:Article
Impact Factor:cited By 1
Uncontrolled Keywords:Aluminum compounds; Carbides; Cost effectiveness; Energy dispersive spectroscopy; Etching; Field emission displays; Field emission microscopes; Fluorine compounds; Fourier transform infrared spectroscopy; Hydrochloric acid; Lithium Fluoride; Oxide minerals; Oxygen; Scanning electron microscopy; Screening; Titanium dioxide; Titanium metallography; Voltammetry; X ray photoelectron spectroscopy, Biomolecular immobilization; Biosensing systems; Elemental compositions; Energy dispersive X ray spectroscopy; Field emission scanning electron microscopy; Limit of detection; Sweep voltammetry; Titanium aluminum carbide, Aluminum metallography, aluminum; fluorine; glutaraldehyde; hydrochloric acid; inorganic compound; lithium fluoride; mxene; nanocomposite; ochratoxin; oxygen; plant extract; titanium carbide; unclassified drug; vomitoxin; zearalenone, affinity labeling; Article; binding affinity; biocompatibility; centrifugation; cost effectiveness analysis; field emission scanning electron microscopy; fluorescence resonance energy transfer; Fourier transform infrared spectroscopy; human; immobilization; immunoaffinity chromatography; layer by layer deposition; limit of detection; linear sweep voltammetry; morphology; powder; scanning electron microscopy; sensitivity analysis; sensitivity and specificity; surface plasmon resonance; surface property; vacuum; voltammetry; X ray photoemission spectroscopy; X ray spectroscopy
ID Code:23726
Deposited By: Ms Sharifah Fahimah Saiyed Yeop
Deposited On:19 Aug 2021 09:40
Last Modified:19 Aug 2021 09:40

Repository Staff Only: item control page