Microbial biocompatibility of phosphonium- and ammonium-based ionic liquids

Sivapragasam, M. and Jaganathan, J.R. and Levêque, J.-M. and Moniruzzaman, M. and Abdul Mutalib, M.I. (2019) Microbial biocompatibility of phosphonium- and ammonium-based ionic liquids. Journal of Molecular Liquids, 273 . pp. 107-115.

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This present study is dedicated to the synthesis, characterization and microbial toxicity assessment of phosphonium- and ammonium-based ionic liquids (ILs) bearing four different anions phenylalalinate (Phe), taurinate (Tau), hydroxide (OH), and acetate (Ac). The structures of the subsequent ILs were confirmed by 1H and 13C nuclear magnetic resonance (NMR). Physicochemical properties such as density, thermal stability, conductivity, surface tension, and refractive index were measured. Subsequently, the in vitro toxicity profiles of the ILs were determined for selected Gram-positive and Gram-negative bacteria in terms of inhibition zones (IZ), minimum inhibitory concentrations (MIC), and minimum bactericidal concentrations (MBC). The results showed that the ILs were in the range of �practically harmless� to �harmless�. The order of the same was OH > Ac > Tau > Phe, with phenylalalinate being the most toxic anion owing to its aromatic nature. With reference to the experimental results, the nature of the critical micellar concentrations and water octanol partitioning was discussed in the context of microbial toxicity. Hence, it was shown that anions, rather than cations, were the major contributors to toxicity. © 2018 Elsevier B.V.

Item Type:Article
Impact Factor:cited By 2
Uncontrolled Keywords:Amino acids; Bacteria; Biocompatibility; Ionic liquids; Negative ions; Nuclear magnetic resonance; Refractive index; Thermodynamic properties, Critical micellar concentrations; Gram-negative bacteria; Ionic liquid (ils); Microbial toxicity; Minimum bactericidal concentration (MBC); Minimum inhibitory concentration; Nuclear Magnetic Resonance (NMR); Physicochemical property, Toxicity
Departments / MOR / COE:Research Institutes > Institute for Contaminant Management
ID Code:22244
Deposited By: Ahmad Suhairi
Deposited On:28 Feb 2019 02:51
Last Modified:27 Mar 2019 02:01

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