Potential of Chitosan and its derivatives for controlled drug release applications � A review

Safdar, R. and Omar, A.A. and Arunagiri, A. and Regupathi, I. and Thanabalan, M. (2019) Potential of Chitosan and its derivatives for controlled drug release applications � A review. Journal of Drug Delivery Science and Technology, 49 . pp. 642-659.

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Recent research on the drug delivery systems exhibited tremendous improvements for several short life drugs which disappear in few minutes in harsh conditions of the Gastrointestinal tract (GIT). After years of investigations, the current drug delivery system has been improved with new advanced materials with less toxicity and better therapeutic efficiency. In this regard, new formulations consisting of drugs encapsulated with natural biodegradable copolymer, Chitosan, in the form of nanoparticles have been studied, which in turn improved the release profile of drugs. In this review, the Chitosan and its physiochemical properties, nanoparticles and their drug release mechanism and effects of modification of various drugs (anti�cancer, anti�inflammatory, anti�diabetes, anti�infectious drugs etc) with Chitosan and co�materials on their release profiles are briefly reviewed. These biodegradable polymeric nanoparticles improved the in vitro release profile of drugs and provided a way forward for further improvement of the current and conventional drug delivery systems. © 2018 Elsevier B.V.

Item Type:Article
Impact Factor:cited By 1
Uncontrolled Keywords:chitosan; chitosan derivative; chitosan nanoparticle; curcumin; cyclosporine; doxorubicin; fluorouracil; insulin; isoniazid; nanocarrier; nanoparticle; paclitaxel; podophyllotoxin; salazosulfapyridine, antibacterial activity; antidiabetic activity; antiinflammatory activity; antineoplastic activity; biodegradability; controlled drug release; cross linking; deacetylation; drug delivery system; drug solubility; gastrointestinal tract; human; hydrophobicity; in vitro study; molecular weight; nanoencapsulation; particle size; pH; physical chemistry; polymerization; Review; suspension; zeta potential
ID Code:22164
Deposited By: Ahmad Suhairi
Deposited On:28 Feb 2019 05:47
Last Modified:28 Feb 2019 05:47

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