Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen

Tan, W.-N. and Lim, J.-Q. and Afiqah, F. and Nik Mohamed Kamal, N.N.S. and Abdul Aziz, F.A. and Tong, W.-Y. and Leong, C.-R. and Lim, J.-W. (2018) Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen. Natural Product Research, 32 (7). pp. 854-858.

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Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9) and palmitic acid (21.9), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5) and β-caryophyllene (16.9). Treatment of MCF-7 cells using EO-L (100 μg/mL) caused more than 50 cell death while EO-SB did not induce cytotoxic effect. EO-L has stimulated the growth of BEAS-2B normal cells, but not in MCF-7 cancerous cells. The IC50 of EO-L in MCF-7 and BEAS-2B cells were 71 and 95 μg/mL, respectively. A combination treatment of EO-L and tamoxifen induced more cell death than the treatment with drug alone at lower doses. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type:Article
Impact Factor:cited By 0
Uncontrolled Keywords:beta farnesene; caryophyllene; essential oil; palmitic acid; palmitoleic acid; tamoxifen; antineoplastic agent; beta-farnesene; essential oil; sesquiterpene; tamoxifen, antiproliferative activity; Article; bark; BEAS-2B cell line; cancer inhibition; cell death; cell growth; cell viability; chemical composition; concentration response; controlled study; drug cytotoxicity; drug effect; Garcinia; Garcinia atroviridis; growth inhibition; human; human cell; hydrodistillation; IC50; mass fragmentography; MCF-7 cell line; MTT assay; plant leaf; cell proliferation; chemistry; drug screening; Garcinia; medicinal plant, Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Drug Screening Assays, Antitumor; Garcinia; Gas Chromatography-Mass Spectrometry; Humans; MCF-7 Cells; Oils, Volatile; Plant Bark; Plant Leaves; Plants, Medicinal; Sesquiterpenes; Tamoxifen
ID Code:21634
Deposited By: Ahmad Suhairi
Deposited On:01 Aug 2018 02:56
Last Modified:01 Aug 2018 02:56

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