Development of collagen/PVA composites patches for osteochondral defects using a green processing of ionic liquid

Iqbal, B. and Muhammad, N. and Rahim, A. and Iqbal, F. and Sharif, F. and Safi, S.Z. and Khan, A.S. and Gonfa, G. and Uroos, M. and Rehman, I.U. (2018) Development of collagen/PVA composites patches for osteochondral defects using a green processing of ionic liquid. International Journal of Polymeric Materials and Polymeric Biomaterials . pp. 1-7.

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Osteochondral defects are still a big challenge for the surgeons because of good biocompatibility and higher mechanical strength requiring issues of the implants. In this study, different concentrations of collagen (dissolved in ionic liquid) up to 60 were blended with polyvinyl alcohol to prepare hydrogels of good mechanical strength, with the best biocompatibility and excellent fluid uptake ability. Ionic liquid was used as a green solvent for dissolution of collagen at a higher concentration as compared to other normal solvents. The prepared hydrogels were characterized with Fourier transform infrared spectroscopy (FTIR) which showed the characteristic peaks assigned to collagen and PVA. The surface morphology was investigated using scanning electron microscopy (SEM) which revealed homogeneity of the composite patches. Thermal gravimetric analysis (TGA) performed for samples show good thermal stabilities. Fluid uptake ability showed the massive uptake of fluid by the hydrogels. Biocompatibility was tested using hemolysis and MTT assay. Electrodynamic fatigue testing system was used for evaluating the mechanical properties and measured the tensile strength in the range of 2.4 to 8.5�MPa. The prepared osteochondral patches show good biocompatibility and mechanical properties. © 2018 Taylor & Francis

Item Type:Article
Impact Factor:cited By 0; Article in Press
Uncontrolled Keywords:Biocompatibility; Characterization; Collagen; Fatigue testing; Fourier transform infrared spectroscopy; Gravimetric analysis; Hydrogels; Ionic liquids; Mechanical properties; Scanning electron microscopy; Tensile strength; Tensile testing; Thermogravimetric analysis, Characteristic peaks; Composite patches; Fluid uptake; Green processing; Green solvents; Osteochondral; Osteochondral defects; Thermal gravimetric analyses (TGA), Ionic strength
ID Code:21505
Deposited By: Ahmad Suhairi
Deposited On:01 Aug 2018 03:15
Last Modified:01 Aug 2018 03:15

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