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Synthesis and characterization of cellulose and hydroxyapatite-carbon electrode composite for trace plumbum ions detection and its validation in blood serum

Ajab, H. and Dennis, J.O. and Abdullah, M.A. (2018) Synthesis and characterization of cellulose and hydroxyapatite-carbon electrode composite for trace plumbum ions detection and its validation in blood serum. International Journal of Biological Macromolecules, 113 . pp. 376-385.

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Abstract

A novel synthesis and characterization of cellulose, hydroxyapatite and chemically-modified carbon electrode (Cellulose-HAp-CME) composite was reported for the analysis of trace Pb(II) ions detection and its validation in blood serum. The Field Emission Scanning Electron Microscopy (FESEM) analyses showed that the composite retained the orderly porous structure but with scattered particle size agglomeration. The Fourier Transform Infrared Spectroscopy (FTIR) spectra suggested the presence of functional groups associated with the bending and stretching of carbon bonds and intermolecular H-bonding. X�ray Diffraction (XRD) analyses further elucidated that the crystallite size could have influenced the properties of the electrode. Based on Thermo-gravimetric Analysis (TGA/DTG), the composites showed thermal stability with more than 60 residual content at 700 °C. The sensor was successfully developed for trace Pb(II) ions detection in complex medium such as blood serum, in the physiologically relevant range of 10�60 ppb, with resulting Limit of Detection (LOD) of 0.11 ± 0.36 ppb and Limit of Quantification (LOQ) of 0.36 ± 0.36 ppb. The newly fabricated electrode could be advantageous as a sensing platform with favourable electrochemical characteristics for robust, in situ and rapid environmental and clinical analyses of heavy metal ions. © 2018

Item Type:Article
Impact Factor:cited By 0
Uncontrolled Keywords:cellulose; hydroxyapatite; lead, Article; blood analysis; carbon electrode; electrochemical analysis; energy dispersive X ray spectroscopy; field emission scanning electron microscopy; human; hydrogen bond; infrared spectroscopy; limit of detection; limit of quantitation; particle size; physical chemistry; porosity; synthesis; thermogravimetry; thermostability; X ray diffraction
Departments / MOR / COE:Research Institutes > Institute for Autonomous Systems
ID Code:21473
Deposited By: Ahmad Suhairi
Deposited On:25 Sep 2018 06:31
Last Modified:09 Nov 2018 05:43

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